郵箱: ting.qi@sinh.ac.cn
所屬部門: 計(jì)算生物學(xué)重點(diǎn)實(shí)驗(yàn)室
2024-至 今：中國(guó)科學(xué)院上海營(yíng)養(yǎng)與健康研究所??研究員
2020-2024年：西湖大學(xué)??副研究員
2016-2020年：澳大利亞昆士蘭大學(xué)??博士后
2011-2016年：浙江大學(xué)??數(shù)量遺傳學(xué)??博士
2007-2011年：揚(yáng)州大學(xué)??農(nóng)學(xué)??學(xué)士
統(tǒng)計(jì)遺傳學(xué)，基因組學(xué)，生物信息學(xué)
課題組主要致力于統(tǒng)計(jì)遺傳學(xué)、多組學(xué)（如基因組、轉(zhuǎn)錄組、表觀遺傳組）研究以及人類復(fù)雜性狀和疾?。ㄈ缫钟舭Y、阿爾茨海默癥、帕金森氏癥、精神分裂癥）的大數(shù)據(jù)分析。通過(guò)結(jié)合統(tǒng)計(jì)遺傳學(xué)方法和組學(xué)大數(shù)據(jù)，祁婷博士在鑒定疾病易感基因及解析復(fù)雜性狀和疾病的遺傳調(diào)控機(jī)理等方面積累了豐富的研究經(jīng)驗(yàn)。目前，課題組的主要研究方向包括但不限于如下幾個(gè)方面：
1）在單細(xì)胞水平上進(jìn)行分子表型(如基因表達(dá)， DNA甲基化)的遺傳學(xué)研究，并探索其與復(fù)雜疾病的關(guān)聯(lián)性；
2）多組學(xué)數(shù)據(jù)整合鑒定復(fù)雜疾病的治療靶點(diǎn)和生物標(biāo)記物；
3）統(tǒng)計(jì)遺傳學(xué)分析方法和軟件開發(fā)。
1.?Qi T. #,*?et al.?From genetic associations to genes: methods, applications, and challenges. Trends in Genetics (2024)
2.?Zhang?R.?#, Fang J.?#, Qi T. #?et al.?Maternal aging drives offspring adult trait formation via aged mitochondria. Cell Research?33, 821-834 (2023) (#Co-first author; Cover story)
3.?Qi T.,?Wu Y., Fang H., Zhang F., Liu S., Zeng J., Yang J. Genetic control of RNA splicing and its distinct role in complex trait variation. Nature Genetics?54, 1355-1363 (2022)
4.?Wu Y.#, Qi T.#, Wang?H., Zhang?F.,?Zheng?Z., Phillips-Cremins J.E., Deary?I.J., McRae?A.F., Wray?N.R., Zeng?J., Yang J. Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data. Nature Communications?11, 2061 (2020) (#Co-first author)
5.?Qi T., Wu Y., Zeng J., Zhang F., Xue A., Jiang L., Zhu Z., Kemper K., Yengo L., Zheng Z., eQTLGen Consortium, Marioni R.E., Montgomery G.W., Deary I.J., Wray N.R., Visscher P.M., McRae A.F., Yang J.?Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood. Nature Communications?9, 2282?(2018)
6.?Qi T., Cao Y., Cao L., Gao Y., Zhu S., Lou X., Xu H. Dissecting genetic architecture underlying seed trait in multiple environment. Genetics?199, 61-71 (2015)
7.?Qi T., Jiang B., Zhu Z., Wei C., Gao Y., Zhu S., Xu H., Lou X. Mixed linear model approach for mapping quantitative trait loci underlying crop seed traits. Heredity?113, 224 (2014)
8.?Trubetskoy V., Pardinas A.,?Qi T.?et al. Mapping genomic loci implicates genes and synaptic biology in schizophrenia. Nature?604, 502-508 (2022)
9.?Sun X., Xue A., Qi T., Chen D., Shi D., Wu Y., Zheng Z., Zeng J., Yang J. Tumor mutational burden is polygenic and genetically associated with complex traits and diseases. Cancer Research?85, 1230-1239 (2021)
10.?Jiang L., Zheng Z., Qi T., Kemper K., Wray N.R., Visscher P.M., Yang J.?A resource-efficient tool for mixed model association analysis of large-scale data. Nature Genetics 51, 1749-1755?(2019)?
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