郵箱: ycxiao@sinh.ac.cn
電話: +86-21-54923276
所屬部門: 腫瘤與微環(huán)境重點(diǎn)實(shí)驗(yàn)室
2017-至 今：中國(guó)科學(xué)院上海營(yíng)養(yǎng)與健康研究所 研究員
2015-2016年：中國(guó)科學(xué)院上海生命科學(xué)研究院/上海交通大學(xué)醫(yī)學(xué)院健康科學(xué)研究所 研究員
2010-2015年：MD Anderson Cancer Center 博士后
2007-2010年：中國(guó)科學(xué)院上海生命科學(xué)研究院 博士
免疫衰老的調(diào)控及致病機(jī)制
????生理衰老的過(guò)程中，免疫系統(tǒng)最先開(kāi)始發(fā)生衰老。免疫衰老會(huì)導(dǎo)致免疫細(xì)胞出現(xiàn)功能失衡，主要體現(xiàn)為外周適應(yīng)性免疫細(xì)胞或固有免疫細(xì)胞增殖、活化或分化異常，組織內(nèi)固有免疫細(xì)胞發(fā)生炎性功能失衡等，這種由衰老導(dǎo)致的免疫失衡是誘發(fā)自身免疫病、腫瘤、神經(jīng)退行性疾病等衰老相關(guān)疾病的關(guān)鍵，因此，解析免疫衰老的調(diào)控作用及致病機(jī)制對(duì)于應(yīng)對(duì)人口老齡化、及衰老相關(guān)疾病的認(rèn)知與診治具有重要意義。我們主要聚焦衰老的免疫調(diào)控，利用遺傳突變小鼠及相應(yīng)病理模型，結(jié)合臨床病人樣品，主要研究：
1. 衰老機(jī)體的免疫學(xué)特征
2. 衰老導(dǎo)致機(jī)體免疫失衡的分子機(jī)理
3. 免疫衰老調(diào)控相關(guān)慢性疾病的作用機(jī)制
1.?Hao S#, Zhang S#, Ye J#, Chen L, Wang Y, Pei S, Zhu Q, Xu J, Tao Y, Zhou N, Yin H, Duan CW, Mao C, Zheng M*, Xiao Y*. Goliath induces inflammation in obese mice by linking fatty acid β-oxidation to glycolysis. EMBO Rep 2023 Apr 5;24(4):e56932
2.?Yuan J#, Zhu Q#, Zhang X, Wen Z, Zhang G, Li N, Pei Y, Wang Y, Pei S, Xu J, Jia P, Peng C, Lu W, Qin J, Cao Q*, Xiao Y*. Ezh2 competes with p53 to license lncRNA Neat1 transcription for inflammasome activation. Cell Death Differ 2022 Oct;29(10):2009-2023
3.?Pei S, Huang M, Huang J, Zhu X, Wang H, Romano S, Deng X, Wang Y, Luo Y, Hao S, Xu J, Yu T, Zhu Q, Yuan J, Shen K, Liu Z, Hu G, Peng C, Luo Q*, Wen Z*, Dai D*, Xiao Y*. BFAR coordinates TGFβ signaling to modulate Th9-mediated cancer immunotherapy. J Exp Med 2021 Jul 5;218(7):e20202144
4.?Wang Y, Fu Z, Li X, Liang Y, Pei S, Hao S, Zhu Q, Yu T, Pei Y, Yuan J, Ye J, Fu J, Xu J, Hong J, Yang R, Hou H, Huang X, Peng C, Zheng M*, Xiao Y*. Cytoplasmic DNA sensing by KU complex in aged CD4+ T cell potentiates T cell activation and aging-related autoimmune inflammation. Immunity 2021 Apr 13;54(4):632-647
5.?Huang X#*, Hao S#, Liu J#, Huang Y, Liu M, Xiao C, Wang Y, Pei S, Yu T, Xu J, Wang H, Dai D*, Su X*, Xiao Y*. The ubiquitin ligase Peli1 inhibits ICOS and thereby Tfh-mediated immunity. Cell Mol Immunol 2021 Apr;18(4):969-978
6.?Xu J#, Yu T#, Pietronigro EC, Yuan J, Arioli J, Pei Y, Luo X, Ye J, Constantin G, Mao C*, Xiao Y*. Peli1 impairs microglial Aβ phagocytosis through promoting C/EBPβ degradation. PLoS Biol 2020 Oct 5;18(10):e3000837
7.?Zhu Q, Yu T, Gan S, Wang Y, Pei Y, Zhao Q, Pei S, Hao S, Yuan J, Xu J, Hou F, Wu X, Peng C, Wu P, Qin J, Xiao Y*. TRIM24 facilitates antiviral immunity through mediating K63-linked TRAF3 ubiquitination. J Exp Med 2020 Jul 6;217(7):e20192083
(Recommended by Faculty Opinion)
8.?Yu T#, Gan S#, Zhu Q#, Dai D, Li N, Wang H, Chen X, Hou D, Wang Y, Pan Q, Xu J, Zhang X, Liu J, Pei S, Peng C, Wu P, Romano S, Mao C, Huang M, Zhu X, Shen K, Qin J*, Xiao Y*. Modulation of M2 macrophage polarization by the crosstalk between Stat6 and Trim24. Nat Commun 2019 Sep 25;10(1):4353
9.?Xu J, Pei S, Wang Y, Liu J, Qian Y, Huang M*, Zhang Y*, Xiao Y*. Tpl2 Protects Against Fulminant Hepatitis Through Mobilization of Myeloid-Derived Suppressor Cells. Front Immunol 2019 Aug 20;10:1980
10.?Zhang X, Wang Y, Yuan J, Li N, Pei S, Xu J, Luo X, Mao C, Liu J, Yu T, Gan S, Zheng Q, Liang Y, Guo W, Qiu J, Constantin G, Jin J, Qin J*, Xiao Y*. Macrophage/microglial Ezh2 facilitates autoimmune inflammation through inhibition of Socs3. J Exp Med 2018 May 7;215(5):1365-1382
(Selected and highlighted in J Exp Med 2018;215(5):1269–1271)
11.?Liu J, Huang X, Hao S, Wang Y, Liu M, Xu J, Zhang X, Yu T, Gan S, Dai D, Luo X, Lu Q, Mao C, Zhang Y, Shen N, Li B, Huang M, Zhu X, Jin J, Cheng X, Sun SC, Xiao Y*. Peli1 negatively regulate noncanonical NF-κB signaling to restrain systemic lupus erythematosus. Nat Commun 2018 Mar 19;9(1):1136
12.?Xiao Y#, Zou Q#, Xie X#, Liu T, Li HS, Jie Z, Jin J, Hu H, Manyam G, Zhang L, Cheng X, Wang H, Marie I, Levy DE, Watowich SS, Sun SC*. The kinase TBK1 functions in dendritic cells to regulate T cell homeostasis, autoimmunity, and antitumor immunity. J Exp Med 2017 May 1;214(5):1493-1507 (# Equal contribution)
13.?Xiao Y, Jin J, Chang M, Nakaya M, Hu H, Zou Q, Zhou X, Brittain GC, Cheng X, Sun SC*. TPL2 mediates autoimmune inflammation through activation of the TAK1 axis of IL-17 signaling. J Exp Med 2014 Jul 28;211(8):1689-1702
14.?Xiao Y, Jin J, Chang M, Chang JH, Hu H, Zhou X, Brittain GC, Stansberg C, Torkildsen ？, Wang X, Brink R, Cheng X, Sun SC. Peli1 promotes microglia-mediated CNS inflammation by regulating Traf3 degradation. Nat Med 2013 May;19(5):595-602
(News and Views in Nat Med 2013;19:536-538. Research highlighted in Nat Immunol 2013;14:535)
官方微信
