郵箱: zhangliang01@sinh.ac.cn
電話: +86-21-54923250
所屬部門: 腫瘤與微環(huán)境重點實驗室
2017-至 今：中國科學(xué)院上海營養(yǎng)與健康研究所 研究員
2014-2016年：中國科學(xué)院上海生命科學(xué)研究院/上海交通大學(xué)醫(yī)學(xué)院健康科學(xué)研究所-上海長征醫(yī)院聯(lián)合轉(zhuǎn)化醫(yī)學(xué)中心 研究員
2008-2014年：美國洛克菲勒大學(xué) 博士后
2002-2008年：美國科羅拉多大學(xué)博爾德分校 分子細(xì)胞及發(fā)育生物學(xué)系 博士
2001-2002年：中國疾病預(yù)防控制中心 實習(xí)
1997-2001年：北京大學(xué)生命科學(xué)學(xué)院 生物技術(shù)系 學(xué)士
皮膚干細(xì)胞命運(yùn)調(diào)控與病變
皮膚干細(xì)胞是皮膚生長發(fā)育/穩(wěn)態(tài)維護(hù)/創(chuàng)傷修復(fù)的基礎(chǔ),其功能紊亂與脫發(fā)癥、難愈創(chuàng)傷、皮膚癌等多種皮膚疾病的發(fā)生發(fā)展密切相關(guān)。本研究組致力闡明皮膚干細(xì)胞的命運(yùn)調(diào)控與病變的分子機(jī)制，并以此為基礎(chǔ)探索其在皮膚疾病創(chuàng)傷治療/美容保健/組織工程中的應(yīng)用。
1.?Sun Y*, Xu L*, Li Y*, Lin J, Li H, Gao Y, Huang X, Zhu H, Zhang Y, Wei K, Yang Y, Wu B, Zhang L#, Li Q#, Liu C#. Single-Cell Transcriptomics Uncover Key Regulators of Skin Regeneration in Human Long-Term Mechanical Stretch-Mediated Expansion Therapy. Front Cell Dev Biol 2022 May 30;10:865983
2.?Wu S*, Yu Y*, Liu CY*, Zhang X, Zhu PY, Peng Y, Yan XY, Li Y, Hua P, Li QF#, Wang S#, Zhang L#. Single-cell transcriptomics reveals lineage trajectory of human scalp hair follicle and informs mechanisms of hair graying. Cell Discov 2022 May 24;8(1):49
3.?Yu Y*, Zhang X, Liu FZ, Zhu PY, Zhang LP, Peng Y, Yan XY, Li Y, Hua P, Liu CY#, Li QF#, Zhang L#. A stress-induced miR-31–CLOCK–ERK pathway is a key driver and therapeutic target for skin aging. Nat Aging 2021 Sep;1(9):795-809 (Read fulltext at https://rdcu.be/cucwx)
4.?Liu FZ*, Zhang X, Peng Y, Zhang LP, Yu Y, Hua P, Zhu PY, Yan XY, Li Y, Zhang L#. miR-24 controls the regenerative competence of hair follicle progenitors by targeting Plk3. Cell Rep 2021 Jun 8;35(10):109225
5.?Bao W*, Sun C*, Sun X, He M, Yu H, Yan W, Wen F, Zhang L#, Yang C#. Targeting BCL10 by small peptides for the treatment of B cell lymphoma. Theranostics 2020 Sep 19;10(25):11622-11636
6.?Yang G*, Chen Q, Wen D, Chen Z, Wang J, Chen G, Wang Z, Zhang X, Zhang Y, Hu Q, Zhang L#, Gu Z#. A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth. ACS Nano 2019 Apr 23;13(4):4354-4360
7.?Wu S*, Zhang M*, Yang X*, Peng F, Zhang J, Tan J, Yang Y, Wang L, Hu Y, Peng Q, Li J, Liu Y, Guan Y, Chen C, Hamer MA, Nijsten T, Zeng C, Adhikari K, Gallo C, Poletti G, Schuler-Faccini L, Bortolini MC, Canizales-Quinteros S, Rothhammer F, Bedoya G, Gonzalez-Jose R, Li H, Krutmann J, Liu F, Kayser M, Ruiz-Linares A, Tang K, Xu S, Zhang L#, Jin L#, Wang S#. Genome-wide association studies and CRISPR/Cas9-mediated gene editing identify regulatory variants influencing eyebrow thickness in humans. PLoS Genet 2018 Sep 24;14(9):e1007640
8.?Ge YJ*, Zhang L*, Nikolova M, Reva B, Fuchs E#. Strand-specific in vivo screen of 169 cancer-associated miRs unveils key drivers and oncogenic targets. Nat Cell Biol 2016 Jan;18(1):111-121
9.?Zhang L*, Ge YJ, Fuchs E#. miR-125b can enhance skin tumor initiation and promote malignant progression by repressing differentiation and prolonging cell survival. Genes Dev 2014 Nov 15;28(22):2532-2546 (Cover story)
10.?Zhang L*, Stokes N, Polak L, Fuchs E#. Specific MicroRNAs Are Preferentially Expressed by Skin Stem Cells To Balance Self-Renewal and Early Lineage Commitment. Cell Stem Cell 2011 Mar 4;8(3):294-308 (Cover story)
11.?Zhang L*, Hammell M, Kudlow BA, Ambros V, Han M#. Systematic analysis of dynamic miRNA-target interactions during C. elegans development. Development 2009 Sep;136(18):3043-3055
12.?Zhang L*, Ding L*, Cheung TH, Dong MQ, Chen J, Sewell AK, Liu X, Yates JR 3rd, Han M#. Systematic Identification of C. elegans miRISC Proteins, miRNAs, and mRNA Targets by Their Interactions with GW182 Proteins AIN-1 and AIN-2. Mol Cell 2007 Nov 30;28(4):598-613
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