| Organoids-on-Chips Technology: Unveiling New Perspectives in Rare-Disease Research |
| 論文作者 |
Li, XY; Wang, H; You, XY; Zhao, GP |
| 期刊/會(huì)議名稱(chēng) |
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES |
| 論文年度 |
2025 |
| 論文類(lèi)別 |
|
| 摘要 |
The scarcity of robust models and therapeutic options for rare diseases continues to hamper their preclinical investigation. Traditional animal models and two-dimensional cell cultures are limited in their ability to replicate human heredity-associated traits and complex pathological features. Organoids-on-a-chip approaches open up new frontiers in rare-disease research via the integration of organ chips and organoid technology. This integrative strategy offers immense opportunities for the mimicry of disease-related traits, the clarification of the mechanisms underlying disease, and the prediction of treatment responses in a highly human-related manner. This forward-looking perspective suggests organoids on chips are transformative tools for parsing rare-disease pathogenesis, accelerating therapeutic discovery, and bridging the gap between basic research and precision medicine. |
| 卷 |
26 |
| 影響因子 |
4.9 |
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