| Colchicine prophylaxis is associated with fewer gout flares after COVID-19 vaccination |
| 論文作者 |
Lu, J; He, YW; Terkeltaub, R; Sun, MS; Ran, ZJ; Xu, XM; Wang, C; Li, XD; Hu, SH; Xue, XM; Yan, F; Zhang, H; Yin, HY; Shi, YY; Dalbeth, N; Li, CG |
| 期刊/會議名稱 |
ANNALS OF THE RHEUMATIC DISEASES |
| 論文年度 |
2022 |
| 論文類別 |
Article; Early Access |
| 摘要 |
Objectives COVID-19 vaccination often triggers a constellation of transitory inflammatory symptoms. Gout is associated with several comorbidities linked to poor outcomes in COVID-19, and gout flares can be triggered by some vaccinations. We analysed the risk of gout flares in the first 3 months after COVID-19 vaccination with inactivated virus, and whether colchicine can prevent gout flares following post-COVID-19 vaccination. Methods A clinical delivery population-based cross-sectional study was conducted in the Gout Clinic at the Affiliated Hospital of Qingdao University between February and October 2021. Study participants were selected using a systematic random sampling technique among follow-up patients with gout. We collected data, including vaccinations and potential risk factors, using a combination of interviews, health QR codes and medical records. Logistic regression was used to adjust for covariates. Results We enrolled 549 gout participants (median age 39 years, 84.2% vaccinated). For the 462 patients who received COVID-19 vaccine, 203 (43.9%) developed at least one gout flare in the 3 months after vaccination. Most of these flares were experienced within 1 month after the first (99/119 (83.2%)) or second (70/115 (60.9%)) dose of vaccine. Compared with unvaccinated participants, COVID-19 vaccination was associated with higher odds of gout flare within 3 months (adjusted OR 6.02; 95% CI 3.00 to 12.08). Colchicine use was associated with 47% less likelihood of postvaccine gout flare. Conclusion COVID-19 vaccination was associated with increased odds of gout flare, which developed mainly in month 1 after each vaccine dose, and was negatively associated with colchicine prophylaxis. |
| 期 |
8 |
| 卷 |
81 |
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